Located in the heart of Newport Beach’s scenic Back Bay, 375 Santa Isabel Avenue is a rare offering that perfectly blends modern luxury with the ease of coastal living. Just moments from iconic Newport destinations—Balboa Island, Fashion Island, the harbor, and world-class beaches—this expansive 5-bedroom, 5.5-bath estate offers the best of both tranquility and connection. Situated on a generous 9,816 square foot lot, the home spans approximately 5,200 square feet of thoughtfully designed living space. A gated private driveway enhances the home&#39's curb appeal, while soaring ceilings, oversized rooms, and walls of glass create a light-filled, airy environment that celebrates Southern California’s indoor-outdoor lifestyle. A stunning central atrium anchors the home, and a unique indoor-outdoor dining space invites year-round entertaining with ease. The kitchen and adjoining scullery (butler’s kitchen) are a chef’s dream, offering function and elegance in equal measure. The spacious first-floor primary suite features a luxurious spa-like bathroom and generous walk-in closet space, creating a true retreat within the home. Upstairs, an open loft overlooks the living space below, adding dimension and flexibility, while a private fitness studio offers even more room to live well. Outside, the landscaping is absolutely stunning, with a beautifully manicured front yard that gracefully wraps around to a backyard designed for celebration. With ample space for events and gatherings, the rear grounds provide the perfect backdrop for al fresco dining, holiday parties, or relaxed summer nights under the stars. Whether you&#39're enjoying peaceful mornings along the Back Bay trails or entertaining friends in the privacy of your own retreat, 375 Santa Isabel Avenue is a one-of-a-kind Newport Beach sanctuary—spacious, stylish, and surrounded by the best of coastal living.